Protein phosphorylation: A potential target in glioma development

Glioma is one of the most common primary brain tumors, and mortality due to this disease second only cardiovascular cerebrovascular diseases. In traditional surgery, it difficult eradicate glioma; often recurrence increases its malignant degree, leading a large number patients killed by disease. It important subjects study pathogenesis explore effective treatment methods. Research on glioma mechanisms mainly focuses effect DNA methylation in epigenetics. Although there are many studies protein phosphorylation, no overall regulatory mechanism. Protein phosphorylation regulates variety cell functions, such as growth, division differentiation, apoptosis. As consequence, plays part various activities glioma, can also be used target regulate development glioma. This review aimed at studying understanding pathological mechanism, an in-depth analysis it. The following discussion migration invasion, resistance death possibility treating phosphorylation.